Application of autologous adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs

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I Sudoma
L Pylyp
Y Kremenska
Y Goncharova*

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Sudoma, I., Pylyp, L., Kremenska, Y., & Goncharova, Y. (2019). Application of autologous adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs. Journal of Stem Cell Therapy and Transplantation, 3(1), 001–008. https://doi.org/10.29328/journal.jsctt.1001013
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Copyright (c) 2019 Sudoma I, et al.

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Check JH, Nowroozi K, Choe L, Dietterich C. The effect of endometrial thickness and echogenic patterns on pregnancy rates during in vitro fertilization. Fertil Steril. 1991; 56: 1173–1175. Ref.: https://goo.gl/aAvLmU

Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C. The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril. 1993; 59; 72–75. Ref.: https://goo.gl/R9S3Ee

Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH. Endometrial pattern and thickness associated with pregnancy outcome after assisted reproductive technologies. Hum Reprod. 1992; 7: 418–421. Ref.: https://goo.gl/QPx5S3

Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995; 10: 919–922. Ref.: https://goo.gl/f4qv5L

Rinaldi L, Lisi F, Floccari A, Lisi R, Pepe G, et al. Endometrial thickness as a predictor of pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection. Hum Reprod. 1996; 11: 1538–1541. Ref.: https://goo.gl/aw9AfU

Yuval Y, Lipitz S, Dor J, Achiron R. The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization. Hum Reprod. 1999; 14: 1067–1071. Ref.: https://goo.gl/bPFSRG

De Geyter C, Schmitter M, De Geyter M, Nieschlag E, Holzgreve W, et al. Prospective evaluation of the ultrasound appearance of the endometrium in a cohort of 1,186 infertile women. Fertil Steril. 2000; 73: 106-113. Ref.: https://goo.gl/ekZcCq

Bassil S. Changes in endometrial thickness, width, length and pattern in predicting pregnancy outcome during ovarian stimulation in in vitro fertilization. Ultrasound Obstet Gynecol. 2001; 18: 258–263. Ref.: https://goo.gl/f1dGzH

Schild RL, Knobloch C, Dorn C, Fimmers R, van der Ven H, et al. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001; 75: 361–366. Ref.: https://goo.gl/dnMFV3

Zhang X, Chen CH, Confino E, Barnes R, Milad M, et al. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization–embryo transfer. Fertil Steril. 2005; 83: 336–340. Ref.: https://goo.gl/MR7bSQ

Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007; 87: 53–59. Ref.: https://goo.gl/cAUXjp

McWilliams GD, Frattarelli JL. Changes in measured endometrial thickness predict in vitro fertilization success. Fertil Steril. 2007; 8: 74-81. Ref.: https://goo.gl/mjLRVA

Gargett CE. Uterine stem cells: What is the evidence? Hum Reprod. 2007; 13: 87–101. Ref.: https://goo.gl/EXicq4

Ono M, Maruyama T, Yoshimura Y. Regeneration and adult stem cells in the human female reproductive tract. Stem Cell Clon. 2008; 1: 23–29. Ref.: https://goo.gl/Tr7tFf

Maruyama T, Masuda H, Ono M, Kajitani T, Yoshimura Y. Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology. Reprod. 2010; 140: 11–22. Ref.: https://goo.gl/rMTjsg

Wolff EF, Wolff AB, Hongling Du, Taylor HS. Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis. Reprod Sci. 2007; 14: 524–533. Ref.: https://goo.gl/2H9zjR

Cervelló I, Mirantes C, Santamaria X, Dolcet X, Matias-Guiu X, et al. Stem cells in human endometrium and endometrial carcinoma. Int J Gynecol Pathol. 2011; 30: 317–327. Ref.: https://goo.gl/m5Gtpj

Gargett CE, Chan RWS, Scahwab KE. Endometrial stem cells. Curr Opin Obstet Gynecol. 2007; 19: 377–383. Ref.: https://goo.gl/Yq297f

Gargett CE, Schwab KE, Zillwood RM, Nguyen HP, Wu D. Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium. Biol Reprod. 2009; 80: 1136–1145. Ref.: https://goo.gl/eV32Ex

Gargett CE, Masuda H. Adult stem cells in the endometrium. Mol Hum Reprod. 2010; 16: 818–834. Ref.: https://goo.gl/69Q1Sr

Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006; 441: 1094–1096. Ref.: https://goo.gl/iDgpXT

Singec I, Jandial R, Crain A, Nikkhah G, Snyder EY. The leading edge of stem cell therapeutics. Annu Rev Med. 2007; 58: 313–328. Ref.: https://goo.gl/VDBKzm

Nagori CB, Panchal SY, Patel H. Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome. J Hum Reprod Sci. 2011; 4: 43–48. Ref.: https://goo.gl/ALX2CX

Sudoma I, Kremenska Y, Pylyp L, Goncharova Y, Zadorozhnaja T, et al. The autologous fat stem cells in the treatment of the atrophic endometrium in women with infertility and the use of ART. Zdoroviye zhenshchiny. 2013; 4: 149-156.

Ogawa R. The importance of adipose-derived stem cells and vascularized tissue regeneration in the field of tissue transplantation. Curr Stem Cell Res Ther. 2006; 1:13–20. Ref.: https://goo.gl/gijwtn

Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7: 211–228. Ref.: https://goo.gl/66Kr2H

Bernacki SH, Wall ME, Loboa EG. Isolation of human mesenchymal stem cells from bone and adipose tissue. Met Cell Biol. 2008; 86: 257– 278. Ref.: https://goo.gl/b9V6va

Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013; 15: 641–648. Ref.: https://goo.gl/2e6ZCe

Korbling M, Estrov Z. Adult stem cells for tissue repair—a new therapeutic concept? N Engl J Med. 2003; 349: 570–582. Ref.: https://goo.gl/c5SV3x

Du H, Taylor HS. Stem cells and reproduction. Curr Opin Obstet Gynecol. 2010; 22: 235–241. Ref.: https://goo.gl/C26k1B

Salem HK, Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cell. 2010; 28: 585–596. Ref.: https://goo.gl/XqemaE

Sudoma I, Kremenska Y, Zukin V, Goncharova Y. Novel treatment for patients with thin endometrium? MSRM International meeting ―Implantation – Recurrent Miscarriages Science and Clinical Aspects, Crete, Greece, 2010; 24-26, 22–23.

Sudoma I, Pylyp L, Goncharova Y, Zukin V. Endometrial regeneration with autologous adipose derived stem cells resulting in pregnancy with donated oocyte embryos. Hum Reprod. 2012; 27: 342–344. Ref.: https://goo.gl/QXMXDj

Check JH, Cohen R. Live fetus following embryo transfer in a woman with diminished egg reserve whose maximal endometrial thickness was less than 4 mm. Clin Exp Obstet Gynecol. 2011; 38: 330–332. Ref.: https://goo.gl/y4op2p

Dix E, Check JH. Successful pregnancies following embryo transfer despite very thin late proliferative endometrium. Fertil Steril. 2008; 89: 15–16. Ref.: https://goo.gl/Bygnf5

Sundström P. Establishment of a successful pregnancy following in-vitro fertilization with an endometrial thickness of no more than 4 mm. Hum. Reprod. 1998; 13: 1550–1552. Ref.: https://goo.gl/og9hnQ