Clinical Study on the Treatment of Type 2 Diabetes with BMPRP
Article Sidebar
Main Article Content
Abstract
Objective To retrospectively analyze the effects of (bone marrow platelet-rich plasma BMPRP) precise pancreatic infusion therapy versus conventional treatment. Methods Bone marrow was collected from the iliac crest anterior superior spine, and platelet-rich plasma was separated by centrifugation. BMPRP was infused into the pancreas under ultrasound guidance. It was compared with conventional hypoglycemic drugs and insulin therapy. Results In the BMPRP treatment group of 32 cases, the fasting blood sugar and hemoglobin A1c were significantly lower than before treatment, while the C-peptide level did not change significantly. The insulin dose was reduced. In the conventional treatment group of 28 cases, the fasting blood sugar, hemoglobin A1c, and C-peptide levels did not change significantly after continuous treatment for one year, and the insulin dose was not reduced. Conclusion BMPRP precise pancreatic infusion therapy can improve pancreatic function, reduce insulin resistance, lower blood sugar, and reduce insulin dosage.
Article Details
Copyright (c) 2025 Baochi Liu, Qiqiang Dong, Ruping Zheng, Xiong Gao, Huaiyuan Chen
This work is licensed under a Creative Commons Attribution 4.0 International License.
The Journal of Stem Cell Therapy and Transplantation is committed in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. In order to use the Open Access paradigm to the maximum extent in true terms as free of charge online access along with usage right, we grant usage rights through the use of specific Creative Commons license.
License: Copyright © 2017 - 2025 | 
Open Access by Journal of Stem Cell Therapy and Transplantation is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at Heighten Science Publications Inc.
With this license, the authors are allowed that after publishing with the journal, they can share their research by posting a free draft copy of their article to any repository or website.
Compliance 'CC BY' license helps in:
| Permission to read and download | ✓ |
| Permission to display in a repository | ✓ |
| Permission to translate | ✓ |
| Commercial uses of manuscript | ✓ |
'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.
Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license.
1. Memon B, Abdelalim EM. Stem cell therapy for diabetes: beta cells versus pancreatic progenitors. Cells. 2020;9(2):283. Available from: https://doi.org/10.3390/cells9020283
2. Zhang S, Chen L, Zhang G, Zhang B. Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages. Stem Cell Res Ther. 2020;11(1):39. Available from: https://doi.org/10.1186/s13287-020-1561-x
3. Su G, Mi S, Tao H, Li Z, Yang H, Zheng H, et al. Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol. 2011;10:19. Available from: https://doi.org/10.1186/1475-2840-10-19
4. Zhang X, Yang X, Sun B, Zhu C. Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review. Commun Biol. 2021;4(1):1366. Available from: https://doi.org/10.1038/s42003-021-02896-3
5. Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ. 2020;369:m997. Available from: https://doi.org/10.1136/bmj.m997
6. Shi L, Tee BC, Sun Z. Effects of porcine bone marrow-derived platelet-rich plasma on bone marrow-derived mesenchymal stem cells and endothelial progenitor cells. Tissue Cell. 2021;71:101587. Available from: https://doi.org/10.1016/j.tice.2021.101587
7. Murphy MB, Blashki D, Buchanan RM, Yazdi IK, Ferrari M, Simmons PJ, et al. Adult and umbilical cord blood-derived platelet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation. Biomaterials. 2012;33(21):5308-16. Available from: https://doi.org/10.1016/j.biomaterials.2012.04.007
8. Park G, Hwang DY, Kim DY, Han JY, Lee E, Hwang H, et al. Identification of CD141+ vasculogenic precursor cells from human bone marrow and their endothelial engagement in the arteriogenesis by co-transplantation with mesenchymal stem cells. Stem Cell Res Ther. 2024;15(1):388. Available from: https://doi.org/10.1186/s13287-024-03994-9
9. Nammian P, Asadi-Yousefabad SL, Daneshi S, Sheikhha MH, Tabei SMB, Razban V. Comparative analysis of mouse bone marrow and adipose tissue mesenchymal stem cells for critical limb ischemia cell therapy. Stem Cell Res Ther. 2021;12(1):58. Available from: https://doi.org/10.1186/s13287-020-02110-x
10. Peng X, Liang B, Wang H, Hou J, Yuan Q. Hypoxia pretreatment improves the therapeutic potential of bone marrow mesenchymal stem cells in hindlimb ischemia via upregulation of NRG-1. Cell Tissue Res. 2022;388(1):105-116. Available from: https://doi.org/10.1007/s00441-021-03562-0
11. Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care. 2019;42(8):1593-1603. Available from: https://doi.org/10.2337/dci19-0028
12. Sassoli C, Vallone L, Tani A, Chellini F, Nosi D, Zecchi-Orlandini S. Combined use of bone marrow-derived mesenchymal stromal cells (BM-MSCs) and platelet rich plasma (PRP) stimulates proliferation and differentiation of myoblasts in vitro: new therapeutic perspectives for skeletal muscle repair/regeneration. Cell Tissue Res. 2018;372(3):549-570. Available from: https://doi.org/10.1007/s00441-018-2792-3
13. Lu J, Wang C, Shen Y, Chen L, Zhang L, Cai J, et al. Time in range in relation to all-cause and cardiovascular mortality in patients with type 2 diabetes: a prospective cohort study. Diabetes Care. 2021;44(2):549-555. Available from: https://doi.org/10.2337/dc20-1862
14. Lee JS, Gillinov SM, Siddiq BS, Dowley KS, Martin SD. Surgical applications for bone marrow aspirate concentrate. Arthroscopy. 2024;40(9):2350-2352. Available from: https://doi.org/10.1016/j.arthro.2024.05.002
15. Li L, Si Y, Cheng M, Lang L, Li A, Liu B. Therapeutic effect of autologous bone marrow cells injected into the liver under the guidance of B ultrasound in the treatment of HBV-related decompensated liver cirrhosis. Exp Ther Med. 2022;24:633. Available from: https://doi.org/10.3892/etm.2022.11570
16. Liu BC, Cheng MR, Lang L, Li L, Si YH, Li AJ, et al. Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study. World J Gastrointest Surg. 2023;15(9):1919-1931. Available from: https://doi.org/10.4240/wjgs.v15.i9.1919
17. Liu B, Gao X, Chen Y, Dong Q, Wang J, Zhao B. B-ultrasound-guided intrahepatic infusion of autologous bone marrow cells for decompensated cirrhosis. Int J Bone Marrow Res. 2024;7(1):001-006. Available from: https://dx.doi.org/10.29328/journal.jbmr.1001017
18. Liu B, Gao X, Chen Y, Zheng R, Dong Q, Wang J. Analysis of clinical data on the treatment of type 2 diabetes with BMPRP. Am J Biosci Bioeng. 2024;12(6):128-134. Available from: https://doi.org/10.11648/j.bio.20241206.14
19. Wang X, Zhao X, Dorje T, Yan H, Qian J, Ge J. Glycemic variability predicts cardiovascular complications in acute myocardial infarction patients with type 2 diabetes mellitus. Int J Cardiol. 2014;172(2):498-500. Available from: https://doi.org/10.1016/j.ijcard.2014.01.015
20. Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes. 2008;57(5):1349-1354. Available from: https://doi.org/10.2337/db08-0063
21. Saboo B, Kesavadev J, Shankar A, Krishna MB, Sheth S, Patel V, et al. Time-in-range as a target in type 2 diabetes: an urgent need. Heliyon. 2021;7(1):e05967. Available from: https://doi.org/10.1016/j.heliyon.2021.e05967