Figure 1

Exploring Environmental Neurotoxicity Assessment Using Human Stem Cell-Derived Models

Narimane Kebieche*, Farzana Liakath Ali, Seungae Yim, Mohamed Ali, Claude Lambert and Rachid Soulimani

Published: 15 November, 2024 | Volume 8 - Issue 1 | Pages: 054-068

jsctt-aid1044-p001

Figure 1:

Comparison of 2D and 3D Cell Culture Models in Neurotoxicity Assessment. (A) Cell Culture Systems: (A.a) Traditional 2D cell culture on flat surfaces; (A.b) 3D cell culture systems, including scaffold-free methods (using ultra-low attachment or ECM-coated plates) and scaffold-based systems with rigid or soft biomaterials (e.g., hydrogels) that mimic ECM architecture. (B) Neurotoxicity Assessment and Chemical Screening: iPSC-derived 2D and 3D models are applied to screen and evaluate the neurotoxicity of chemicals using key neurotoxicity endpoints. (Figures created with BioRender.com).

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001044 Cite this Article Read Full Article PDF

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