Abstract

Editorial

Autologous hematopoietic stem cell transplantation in systemic sclerosis patientss

Eleftherios Pelechas* and Panagiota Karagianni

Published: 27 February, 2020 | Volume 4 - Issue 1 | Pages: 001-002

ystemic sclerosis (SScl) is an autoimmune disorder of unknown aetiology, characterised by fibrosis and microvascular injury of the affected organs. The hallmark of the disease is thickening and tightness of the skin and the subcutaneous tissue. SScl can affect virtually any organ systems, most importantly the skin, blood vessels, lungs, kidneys, gastrointestinal tract, and the heart [1].

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001019 Cite this Article Read Full Article PDF

Keywords:

Autologous hematopoietic stem cell transplantation; Systemic sclerosis; Autoimmunity; Immunosuppression

References

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  7. Burt RK, Shah SJ, Dill K, Grant T, Gheorghiade M, et al. Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomized phase 2 trial. Lancet. 2011; 378: 498-506. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21777972
  8. van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, et al. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. JAMA. 2014; 311: 2490-2498. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25058083
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  11. Sullivan KM, Majhail NS, Bredeson C, Carpenter PA, Chatterjee S, et al. Systemic sclerosis as an indication for autologous hematopoietic cell transplantation: position statement from the American society for blood and marrow transplantation. Biol Blood Marrow Transplant. 2018; 24: 1961-1964. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29953945

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