One of the factors of assisted reproduction technology (ART) success is an adequate growth and development of endometrium. At the end of follicular phase of menstrual cycle endometrium reaches its greatest thickness. It is believed that there is a critical limit of endometrial thickness beyond which the implantation of embryo is unlikely or impossible [1-5]. In practice of ART programs ultrasound measurement of endometrial thickness is used to evaluate uterine lining growth. Scientific literature is debatable as to what thickness of endometrium should be considered optimal, some researchers emphasize the negative impact of “thin endometrium” on the success of ART programs [1-12], while others do not agree [6,7,9]. Nevertheless, when endometrial thickness in ART program does not exceed 6 mm the chance of pregnancy occurring is very low (Kumbak B, et al. 2009).
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Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C. The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril. 1993; 59; 72–75. Ref.: https://goo.gl/R9S3Ee
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Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995; 10: 919–922. Ref.: https://goo.gl/f4qv5L
Rinaldi L, Lisi F, Floccari A, Lisi R, Pepe G, et al. Endometrial thickness as a predictor of pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection. Hum Reprod. 1996; 11: 1538–1541. Ref.: https://goo.gl/aw9AfU
Yuval Y, Lipitz S, Dor J, Achiron R. The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization. Hum Reprod. 1999; 14: 1067–1071. Ref.: https://goo.gl/bPFSRG
De Geyter C, Schmitter M, De Geyter M, Nieschlag E, Holzgreve W, et al. Prospective evaluation of the ultrasound appearance of the endometrium in a cohort of 1,186 infertile women. Fertil Steril. 2000; 73: 106-113. Ref.: https://goo.gl/ekZcCq
Bassil S. Changes in endometrial thickness, width, length and pattern in predicting pregnancy outcome during ovarian stimulation in in vitro fertilization. Ultrasound Obstet Gynecol. 2001; 18: 258–263. Ref.: https://goo.gl/f1dGzH
Schild RL, Knobloch C, Dorn C, Fimmers R, van der Ven H, et al. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001; 75: 361–366. Ref.: https://goo.gl/dnMFV3
Zhang X, Chen CH, Confino E, Barnes R, Milad M, et al. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization–embryo transfer. Fertil Steril. 2005; 83: 336–340. Ref.: https://goo.gl/MR7bSQ
Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007; 87: 53–59. Ref.: https://goo.gl/cAUXjp
Gargett CE. Uterine stem cells: What is the evidence? Hum Reprod. 2007; 13: 87–101. Ref.: https://goo.gl/EXicq4
Ono M, Maruyama T, Yoshimura Y. Regeneration and adult stem cells in the human female reproductive tract. Stem Cell Clon. 2008; 1: 23–29. Ref.: https://goo.gl/Tr7tFf
Maruyama T, Masuda H, Ono M, Kajitani T, Yoshimura Y. Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology. Reprod. 2010; 140: 11–22. Ref.: https://goo.gl/rMTjsg
Wolff EF, Wolff AB, Hongling Du, Taylor HS. Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis. Reprod Sci. 2007; 14: 524–533. Ref.: https://goo.gl/2H9zjR
Cervelló I, Mirantes C, Santamaria X, Dolcet X, Matias-Guiu X, et al. Stem cells in human endometrium and endometrial carcinoma. Int J Gynecol Pathol. 2011; 30: 317–327. Ref.: https://goo.gl/m5Gtpj
Gargett CE, Schwab KE, Zillwood RM, Nguyen HP, Wu D. Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium. Biol Reprod. 2009; 80: 1136–1145. Ref.: https://goo.gl/eV32Ex
Gargett CE, Masuda H. Adult stem cells in the endometrium. Mol Hum Reprod. 2010; 16: 818–834. Ref.: https://goo.gl/69Q1Sr
Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006; 441: 1094–1096. Ref.: https://goo.gl/iDgpXT
Singec I, Jandial R, Crain A, Nikkhah G, Snyder EY. The leading edge of stem cell therapeutics. Annu Rev Med. 2007; 58: 313–328. Ref.: https://goo.gl/VDBKzm
Nagori CB, Panchal SY, Patel H. Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome. J Hum Reprod Sci. 2011; 4: 43–48. Ref.: https://goo.gl/ALX2CX
Sudoma I, Kremenska Y, Pylyp L, Goncharova Y, Zadorozhnaja T, et al. The autologous fat stem cells in the treatment of the atrophic endometrium in women with infertility and the use of ART. Zdoroviye zhenshchiny. 2013; 4: 149-156.
Ogawa R. The importance of adipose-derived stem cells and vascularized tissue regeneration in the field of tissue transplantation. Curr Stem Cell Res Ther. 2006; 1:13–20. Ref.: https://goo.gl/gijwtn
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7: 211–228. Ref.: https://goo.gl/66Kr2H
Bernacki SH, Wall ME, Loboa EG. Isolation of human mesenchymal stem cells from bone and adipose tissue. Met Cell Biol. 2008; 86: 257– 278. Ref.: https://goo.gl/b9V6va
Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013; 15: 641–648. Ref.: https://goo.gl/2e6ZCe
Korbling M, Estrov Z. Adult stem cells for tissue repair—a new therapeutic concept? N Engl J Med. 2003; 349: 570–582. Ref.: https://goo.gl/c5SV3x
Du H, Taylor HS. Stem cells and reproduction. Curr Opin Obstet Gynecol. 2010; 22: 235–241. Ref.: https://goo.gl/C26k1B
Salem HK, Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cell. 2010; 28: 585–596. Ref.: https://goo.gl/XqemaE
Sudoma I, Kremenska Y, Zukin V, Goncharova Y. Novel treatment for patients with thin endometrium? MSRM International meeting ―Implantation – Recurrent Miscarriages Science and Clinical Aspects, Crete, Greece, 2010; 24-26, 22–23.
Sudoma I, Pylyp L, Goncharova Y, Zukin V. Endometrial regeneration with autologous adipose derived stem cells resulting in pregnancy with donated oocyte embryos. Hum Reprod. 2012; 27: 342–344. Ref.: https://goo.gl/QXMXDj
Check JH, Cohen R. Live fetus following embryo transfer in a woman with diminished egg reserve whose maximal endometrial thickness was less than 4 mm. Clin Exp Obstet Gynecol. 2011; 38: 330–332. Ref.: https://goo.gl/y4op2p
Dix E, Check JH. Successful pregnancies following embryo transfer despite very thin late proliferative endometrium. Fertil Steril. 2008; 89: 15–16. Ref.: https://goo.gl/Bygnf5
Sundström P. Establishment of a successful pregnancy following in-vitro fertilization with an endometrial thickness of no more than 4 mm. Hum. Reprod. 1998; 13: 1550–1552. Ref.: https://goo.gl/og9hnQ
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Bernard J Van Wie*, Arshan Nazempour##, Chrystal R Quisenberry## and Nehal I Abu-LailBernard J Van Wie*,Arshan Nazempour##,Chrystal R Quisenberry##,Nehal I Abu-Lail. Enhancing adipose stem cell chondrogenesis: A study on the roles of dexamethasone, transforming growth factor β3 and ascorbate supplements and their combination. . 2017 doi: 10.29328/journal.jsctt.1001004; 1: 028-051
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