Abstract

Case Report

Nicotinamide as a treatment option of Age-Related Macular Degeneration

Christine Skerka*, Yuchen Lin and Peter F. Zipfel

Published: 21 September, 2017 | Volume 1 - Issue 1 | Pages: 063-065

Age related macular degeneration is a severe disease of mainly elderly people and leads to central vision loss because of the degeneration of the retinal pigment epithelium [1]. Genetic and environmental factors are responsible for the accumulation of extracellular material and deposit formation near the retinal pigment epithelial (RPE) layer, which leads to loss of photoreceptors and induction of chronic inflammation. The deposits are composed of lipids and proteins including many complement proteins, indicating the involvement of the complement system in the degenerative process and chronic inflammation [2]. So far there is no treatment for the dry form of AMD, except nutritional supplementation with antioxidants and vitamins [3]. Combined with a prolonged lifetime expectation in developed countries, AMD is developing to a social and economic burden. Therefore, there is an urgent need for a treatment of AMD that can delay disease manifestation and progression for several years. 

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001006 Cite this Article Read Full Article PDF

References

  1. Whitmore SS, Sohn EH, Chirco KR, Drack AV, Stone EM, et al. Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Prog Retin Eye Res. 2015; 45: 1-29. Ref.: https://goo.gl/84HxeU
  2. Hollyfield JG, Salomon RG, Crabb JW. Proteomic approaches to understanding age-related macular degeneration. Adv Exp Med Biol. 2003; 533: 83-89. Ref.: https://goo.gl/cTzE5Q
  3. Al-Zamil WM, Yassin SA. Recent developments in age-related macular degeneration: a review. Clin Interv Aging. 2017; 12: 1313-1330. Ref.: https://goo.gl/UeZCz6
  4. Saini JS, Corneo B, Miller JD, Kiehl TR, Wang Q, et al. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell. 2017; 20: 635-647. Ref.: https://goo.gl/rUuJCm
  5. Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, et al. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008; 28: 11500-11510. Ref.: https://goo.gl/kH7jna
  6. Maiese K, Chong ZZ, Hou J, Shang YC. The vitamin nicotinamide: translating nutrition into clinical care. Molecules. 2009; 14: 3446-3485. Ref.: https://goo.gl/uAYMfT
  7. Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016; 48: 134-143. Ref.: https://goo.gl/9mywt3
  8. Wang L, Clark ME, Crossman DK, Kojima K, Messinger JD, et al. Abundant lipid and protein components of drusen. PLoS One. 2010; 5: 10329. Ref.: https://goo.gl/oa36ye
  9. Hollyfield JG, Salomon RG, Crabb JW. Proteomic approaches to understanding age-related macular degeneration. Adv Exp Med Biol. 2003; 533: 83-89. Ref.: https://goo.gl/ohJxsj
  10. Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, et al. Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation. 2017; 14: 4. Ref.: https://goo.gl/yzbfzx
  11. Calippe B, Augustin S, Beguier F, Charles-Messance H, Poupel L, et al. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Immunity. 2017; 46: 261-272. Ref.: https://goo.gl/ke5hWL
  12. Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, et al. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity. 2013; 39: 1143-1157. Ref.: https://goo.gl/WrEScT
  13. Hawksworth OA, Coulthard LG, Woodruff TM. Complement in the fundamental processes of the cell. Mol Immunol. 2017; 84: 17-25. Ref.: https://goo.gl/68gxE3
  14. Maiese K, Chong ZZ, Hou J, Shang YC. The vitamin nicotinamide: translating nutrition into clinical care. Molecules. 2009; 14: 3446-3485. Ref.: https://goo.gl/6UVF48

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?